The novel functions of cGMP-specific phosphodiesterase 5 and its inhibitors in carcinoma cells and pulmonary/cardiovascular vessels.
PDE5 is a opener enzyme intricate in the rule of cGMP-specific signaling pathways in usual physiological processes such as smooth muscle contraction and relaxation. For this insight, inhibition of the enzyme can alter those pathophysiological conditions associated with a lowering cGMP level in tissues. For sample, eclectic PDE5 inhibitors, such as sildenafil (Viagra, Pfizer), tadalafil […]